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2005). These results were not astonishing if we think about that PEA can be a badly water‐soluble material, which might Restrict its oral absorption and bioavailability, but they may suggest a brief‐lived motion of PEA, in settlement with The point that this compound is degraded by two distinct hydrolases, that is definitely, NAAA and FAAH. Lat
Central administration of palmitoylethanolamide reduces hyperalgesia in mice through inhibition of NF‐κB nuclear signalling in dorsal root ganglia. Eur J PharmacolAn obvious applicant for additional targets for PEA might be the hydrolytic enzyme FAAH. On this scenario, the higher regional focus of PEA competes Together with the endogenous NAEs a
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